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KMID : 0379520140300030211
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한국독성학회지
2014 Volume.30 No. 3 p.211 ~ p.220
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In Vitro Genotoxicity Assessment of a Novel Resveratrol Analogue, HS-1793
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Jeong Min-Ho
Yang Kwang-Mo
Lee Chang-Geun
Jeong Dong-Hyeok
Park You-Soo
Choi Yoo-Jin
Kim Joong-Sun
Oh Su-Jung
Jeong Soo-Kyung
Jo Wol-Soon
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Abstract
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Resveratrol has received considerable attention as a polyphenol with various biological effects such as anti-inflammatory, anti-oxidant, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. As part of the overall safety assessment of HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, we assessed genotoxicity in three in vitro assays: a bacterial mutation assay, a comet assay, and a chromosomal aberration assay. In the bacterial reverse mutation assay, HS-1793 did not increase revertant colony numbers in S. typhimurium strains (TA98, TA100, TA1535 and TA1537) or an E. coli strain (WP2 uvrA) regardless of metabolic activation. HS-1793 showed no evidence of genotoxic activity such as DNA damage on L5178Y Tk+/? mouse lymphoma cells with or without the S9 mix in the in vitro comet assay. No statistically significant differences in the incidence of chromosomal aberrations following HS-1793 treatment was observed on Chinese hamster lung cells exposed with or without the S9 mix. These results provide additional evidence that HS-1793 is non-genotoxic at the dose tested in three standard tests and further supports the generally recognized as safe determination of HS-1793 during early drug development.
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KEYWORD
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Resveratrol, HS-1793, Bacterial mutation assay, Comet assay, Chromosomal aberration assay, Genotoxicity
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